[Excerpt] On November 18–19, 2004, the Federal Reserve Bank of Chicago and the Joyce Foundation cosponsored a conference at the Chicago Fed, “Job Loss: Causes, Consequences, and Policy Responses,” to bring together researchers, policymakers, and practitioners to discuss job loss from the perspective of both firms and workers. The first day focused on new research findings, with discussion and comment from participants with backgrounds in policy, practice, and research. The second day featured an address by Michael Moskow, president of the Federal Reserve Bank of Chicago, and panel discussions on layoff procedures from the point of view of firms and the post-layoff experience of workers. The balance of this special issue of Economic Perspectives presents papers by our keynote speakers, Lisa Lynch of Tufts University and Henry Farber of Princeton University, and the second-day panel participants. To begin, however, we provide an overview of the research results and discussion from the first day of the conference. This day was organized into three separate sessions. The first focused on the impact of job loss on workers. The second was devoted to the intersection of regulation and job loss. The final session focused on the impacts of job loss on firms. We discuss each of these in turn and then give a brief overview of the contributions of the keynote speakers and second-day participants that are included in this volume. We conclude with an overview of some of the recurring themes of the conference.